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Stable, long-acting mesenchymal stromal cell secretome delivery via injectable starPEG–heparin hydrogels for sustained immunomodulation
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DOI：10.1016/j.jconrel.2026.115196.png)
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Abstract
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• Injectable starPEG–heparin hydrogels enable sustained MSC secretome delivery. • Secretome proteases drive controlled hydrogel remodeling and release. • Balanced cytokine and growth factor release maintained for 14 days. • Released factors retain strong immunomodulatory bioactivity. • Hydrogel delivery suppresses PBMC proliferation and shifts macrophage phenotype.
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