Stage-Dependent Redistribution of Protein–Protein Interaction Propensity in Canonical Wnt/β-Catenin Signaling

Mishel Abdullah

doi:10.1016/j.ydbio.2026.04.013

Stage-Dependent Redistribution of Protein–Protein Interaction Propensity in Canonical Wnt/β-Catenin Signaling

2026-04-29

0

PRE

AI

M

Mishel Abdullah *

N

null Jayadevan

A

Amalkrishnan Therayil

A

Alhan Faiza

N

Nivetha Kumaraguruparan

N

null Kokulakrishna

DOI：10.1016/j.ydbio.2026.04.013

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Abstract

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• Introduces time-resolved framework for developmental signaling analysis • Ensemble docking captures multi-state interaction configurations • SWIS enables context-weighted comparison across developmental stages • Reveals stage-dependent redistribution of interaction features • Provides scalable alternative to MD-based pathway analysis

Keywords:

Protein–Protein Interaction

Wnt/β-Catenin Signaling

Developmental Stages

Ensemble Docking

Context-Weighted Analysis

Stage-Dependent Redistribution of Protein–Protein Interaction Propensity in Canonical Wnt/β-Catenin Signaling

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