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State-dependent sensory gating in olfactory cortex
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DOI：10.1016/j.neuron.2005.02.025.png)
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Abstract
En 中文
Sensory systems show behavioral state-dependent gating of information flow that largely depends on the thalamus. Here we examined whether the statedependent gating occurs in the central olfactory pathway that lacks a thalamic relay. In urethane-anesthetized rats, neocortical EEG showed a periodical alternation between two states: a slow-wave state (SWS) characterized by large and slow waves and a fast-wave state (FWS) characterized by faster waves. Single-unit recordings from olfactory cortex neurons showed robust spike responses to adequate odorants during FWS, whereas they showed only weak responses during SWS. The state-dependent change in odorant-evoked responses was observed in a majority of olfactory cortex neurons, but in only a small percentage of olfactory bulb neurons. These findings demonstrate a powerful state-dependent gating of odor information in the olfactory cortex that works in synchrony with the gating of other sensory systems. They suggest a state-dependent switchover of signal processing modes in the olfactory cortex.
Keywords:
BASAL FOREBRAIN NEURONS
BRAIN-STEM
ODOR MAPS
THALAMOCORTICAL NEURONS
PIRIFORM CORTEX
SLEEP
STIMULATION
OSCILLATION
RESPONSES
THALAMUS