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Static and dynamic alterations of local brain activity in schizophrenia and associations with clinical symptoms and cognitive function
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DOI：10.1016/j.pnpbp.2026.111724.png)
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Abstract
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• Integrating static and dynamic fMRI metrics provides complementary insights into local brain dysfunction in schizophrenia. • Sensorimotor and visual networks exhibit reduced static activity and temporal dynamics. • Striatal, frontal, and limbic circuits show increased static and dynamic activity. • Decreased dynamic activity in the postcentral gyrus links to severe negative symptoms. • Increased static and dynamic activity in the temporal pole correlates with general psychopathology and verbal learning deficits.
Keywords:
schizophrenia
static fMRI
dynamic fMRI
brain activity
clinical symptoms
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