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Stearoyl-CoA desaturases regulate intestinal stem and progenitor cell metabolism and function in response to nutrient abundance

delete2026-08-10
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OA
AI
K
Kubra B. Akkaya-Colak
A
Andrea Keller
M
Maria H. Festing
K
Khushboo Gupta
J
James Sledziona
A
Ayobami Adeniyi
O
Omar West
P
Patrick Stevens
M
Maciej Pietrzak
S
Sue E. Knoblaugh
H
Helaina Walesewicz
D
Dominique A. Baldwin
N
Nicholas Denko
J
Judith A. Simcox
J
James M. Ntambi
S
Steven K. Clinton
M
Maria M. Mihaylova *
DOI：10.1016/j.celrep.2026.117731delete
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Abstract

Abstract

En 中文
• SCD expression is regulated by nutrient abundance and is enriched in the distal intestine • Scd1/2 loss disrupts lipid desaturation, induces ER stress, and impairs ISC maintenance • Oleic acid supplementation rescues defects caused by SCD inhibition in intestinal organoids • SCD deficiency compromises epithelial repair following irradiation and DSS-induced colitis
Keywords:
stearoyl-CoA desaturase
lipid desaturation
stem cell metabolism
nutrient sensing
intestinal injury
intestinal regeneration
metabolic adaptation
ER stress
colitis
CP: metabolism
CP: stem cell research
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Cell Reports cover
Cell Reports
IF:
6.9
Papers:
1.7W
Citations:
10.2W

Organization

T
The Ohio State University
Scholars:
3.7K
Papers: 1.5K
Citations: 7.4W
U
university of wisconsin-madison
Scholars:
2.9K
Papers: 1.2K
Citations: 2
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