.png){kind=icon}
.png){kind=icon}
Return
Stem cell derived exosomes: Emerging cell-free therapeutics for neurodegenerative disorders
.png){kind=icon}
PRE
AI
M
D
DOI：10.4252/wjsc.v18.i3.116226.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis represent a significant global health challenge with limited therapeutic options. In recent years, stem cell-based therapies have shown promise in promoting neural repair and modulating disease progression. However, concerns related to immune rejection, tumorigenicity, and ethical considerations have limited their clinical application. As an alternative, exosomes derived from stem cells have emerged as a novel, acellular therapeutic strategy. These nanoscale extracellular vesicles carry a rich cargo of proteins, lipids, and nucleic acids, capable of modulating neuroinflammation, promoting neuroprotection, and enhancing tissue repair. Their ability to cross the blood-brain barrier and their low immunogenicity make them especially attractive for treating central nervous system disorders. This review highlights the therapeutic potential of stem cell-derived exosomes in the management of neurodegenerative diseases, discussing their mechanisms of action, current research progress, and future clinical applications. The development of exosome-based therapies marks a significant step toward safe, effective, and cell-free neurodegeneration.
Keywords:
Neurodegenerative diseases
Alzheimer's disease
Parkinson's disease
Stroke
Exosomes
Acellular therapy
Journal
IF:
3.6
Papers:
827
Citations:
2.8K
Organization
Cited Papers