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Stereo-reversed E2 unlocks Z-selective C–H functionalization

delete2025-09-18
delete0
PRE
AI
P
Peter J. Verardi
E
Elizabeth A. Ryutov
P
Poulami Mukherjee
R
Rémy F. Lalisse
K
Karina Targos
T
Tetsuya Inagaki
M
M. K. Kelly
I
Ilia A. Guzei
M
Marcel Schreier *
O
Osvaldo Gutiérrez *
Z
Zachary K. Wickens *
DOI：10.1126/science.adv7630delete
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Abstract

Abstract

En 中文
An enduring challenge in organic chemistry is the selective synthesis of Z olefins, carbon-carbon double bonds with the largest substituents on each carbon oriented on the same side of the bond axis. Verardi et al. report a method that electrochemically replaces carbon-hydrogen bonds on olefins with sulfonium groups. Surprisingly, one of the groups then underwent elimination in a Z-selective manner. The other group could then be replaced with a versatile range of substituents that preserve the Z geometry. —Jake S. Yeston

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