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Steroid-dependent regulation of central nervous system remyelination: From gonadal hormones to chemokine signaling
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DOI：10.1016/j.nbd.2026.107545.png)
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Abstract
En 中文
• Gonadal steroids are essential regulators of central nervous system remyelination. • Astrocytes integrate steroid and chemokine signaling in myelin repair. • Androgen receptor (AR)-CXCR4 cooperation promotes remyelination. • Testosterone and estradiol stimulate remyelination through distinct pathways. • Mechanistic insights may guide future remyelination therapies in multiple sclerosis.
Keywords:
Oligodendrocytes
Remyelination
Astrocytes
Androgen receptor
Estradiol
CXCR4
Multiple sclerosis
AR
androgen receptor
ARE
androgen response element
CNS
central nervous system
EAE
experimental autoimmune encephalomyelitis
ER
estrogen receptor
GFAP
glial fibrillary acidic protein
LPC
lysophosphatidylcholine (lysolecithin)
MBP
myelin basic protein
MPZ
myelin protein zero
MS
multiple sclerosis
NAWM
normal-appearing white matter
OPC
oligodendrocyte progenitor cells
PMP22
peripheral myelin protein 22
PNS
peripheral nervous system
PR
progesterone receptor
RRMS
relapsing-remitting phase of multiple sclerosis.
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