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Stimulus-dependent synaptic plasticity underlies neuronal circuitry refinement in the mouse primary visual cortex
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DOI：10.1016/j.celrep.2024.113966.png)
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Abstract
En 中文
Perceptual learning improves our ability to interpret sensory stimuli present in our environment through experience. Despite its importance, the underlying mechanisms that enable perceptual learning in our sensory cortices are still not fully understood. In this study, we used in vivo two -photon imaging to investigate the functional and structural changes induced by visual stimulation in the mouse primary visual cortex (V1). Our results demonstrate that repeated stimulation leads to a refinement of V1 circuitry by decreasing the number of responsive neurons while potentiating their response. At the synaptic level, we observe a reduction in the number of dendritic spines and an overall increase in spine AMPA receptor levels in the same subset of neurons. In addition, visual stimulation induces synaptic potentiation in neighboring spines within individual dendrites. These findings provide insights into the mechanisms of synaptic plasticity underlying information processing in the neocortex.
Keywords:
LONG-TERM POTENTIATION
EXPERIENCE
SPARSE
MEMORY
SELECTIVITY
DYNAMICS
MODEL
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