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Stochastic Thresholds in Hemostasis and Thrombosis: A Multiscale Biophysical Framework from Transcriptional Bursting to Thrombin Propagation
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DOI：10.1016/j.pbiomolbio.2026.05.006.png)
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Abstract
En 中文
• Stochastic thresholds unify gene bursting, platelet adhesion and thrombin dynamics • Pathological clotting reframed as nested first-passage threshold crossings • Worked example: 50% upstream variability shift compounds to 80% rise in risk • Distributional biomarker metrics may outperform mean-based thrombotic risk scores • Identifies cross-scale measurements needed for predictive multiscale modelling
Keywords:
Stochastic thresholds
Hemostasis
Thrombosis
Multiscale modelling
Thrombin dynamics
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4.5
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1.8K
Citations:
4.7K
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