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Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease
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DOI：10.1586/ECP.12.16.png)
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Abstract
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Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity globally, and its development is mainly associated with tobacco/biomass smoke-induced oxidative stress. Hence, targeting systemic and local oxidative stress with agents that can balance the antioxidant/redox system can be expected to be useful in the treatment of COPD. Preclinical and clinical trials have revealed that antioxidants/redox modulators can detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, chromatin remodeling and inflammatory gene expression; and are especially useful in preventing COPD exacerbations. In this review, various novel approaches and problems associated with these approaches in COPD are reviewed.
Keywords:
antioxidants
COPD
glutathione
Nrf2
oxidants
redox
thiol
tobacco smoke
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