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Strong paracrine effects of the SASP from senescent SEO-COPD fibroblasts
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DOI：10.1016/j.heliyon.2026.e45164.png)
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Abstract
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• The SASP from senescent SEO-COPD fibroblasts induces a strong inflammatory response. • The SASP from senescent SEO-COPD fibroblasts reduces decorin levels. • The single SASP protein t-PA might contribute to the reduced decorin levels. • SASP from senescent COPD fibroblasts can have proteolytic effects. • Senescent fibroblasts can contribute to chronic inflammation and ECM dysregulation via their SASP.
Keywords:
COPD
Ageing
Cellular senescence
Senescence-associated secretory phenotype
Lung fibroblast
Decorin
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