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Structural and regulatory principles underlying apicomplexan conoid function
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DOI：10.1016/j.pt.2026.01.002.png)
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Abstract
En 中文
Zeng et al. and Qian et al. reveal in their cryogenic electron microscopy (cryo-EM) studies how apicomplexan parasites extensively remodel tubulin to construct the conoid, a specialized invasion organelle. Distinct microtubule assemblies integrate mechanical support, force generation, and secretion control, providing a structural framework that underpins parasite motility and host cell entry.
Keywords:
Toxoplasma gondii
motility
invasion
microtubules
preconoidal rings
conoid fibers
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