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Structural characterization and biological activities of specialized metabolites from mangrove-derived fungi Aspergillus sp.
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DOI：10.1016/j.phytochem.2026.114878.png)
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Abstract
En 中文
The mangrove ecosystem is a complex ecosystem that supports a wide variety of microorganisms, among which fungi represent one of the largest groups. Aspergillus fungi constitute the dominant component, and these mangrove-derived Aspergillus strains can produce a wealth of specialized metabolites with unique chemical structures and diverse biological activities. In this paper, a total of 346 specialized metabolites isolated from mangrove-derived Aspergillus species over the past five years (January 2020-April 2025) are summarized. These compounds are classified into five major categories: polyketides, terpenoids, alkaloids, peptides, and other types. A total of 134 compounds exhibited biological activities, including anti-inflammatory, cytotoxic, antibacterial, and alpha-glucosidase-inhibitory activities, among which 20 compounds displayed multiple biological activities. These specialized metabolites, which possess unique structures and notable bioactivities, serve as a reference for the development and innovation of new pharmaceuticals.
Keywords:
Mangrove ecosystems
Aspergillus sp.
Specialized metabolites
Chemical structure
Biological activity
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3.4
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