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Structural Conservation, Functional Decline: The Fate of Human OHCU Decarboxylase
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DOI：10.1016/j.biochi.2026.04.002.png)
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Abstract
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• Human URAD encodes a folded OHCU decarboxylase with reduced activity • Structural features of OHCU decarboxylases remain conserved in humans • Human enzyme shows lower stability and activity than zebrafish OHCUd • Simulations reveal altered ligand binding and conformational dynamics • Results support evolutionary decay after uricase loss in hominids
Keywords:
OHCU decarboxylase
structural conservation
functional decline
evolutionary decay
ligand binding
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