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Structure-Governed MXene Quantum Dots for Cancer Theranostics: From Quantum Confinement to Tumor-Selective Catalytic and Photothermal Activation
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DOI：10.1002/adtp.70145.png)
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Abstract
En 中文
MXene quantum dots (MQDs) have recently emerged as a compelling class of nanomaterials for cancer theranostics, owing to their confined electronic structure, multifunctional activation mechanisms, and favorable in vivo performance. In this review, the structure-governed behavior of MQDs is systematically examined and interpreted, highlighting how their quantum-scale architecture influences therapeutic functionality. The chemical and physical origins of functional diversity in MQDs are discussed, with an emphasis on dimensional miniaturization, electronic confinement, and structure-property relationships beyond biological contexts. Building on this foundation, recent advances in tumor-selective catalytic and photothermal activation of MQDs are analyzed, highlighting Fenton-like redox processes, near-infrared photothermal conversion, and synergistic therapeutic modalities supported by in vivo evidence. Particular attention is given to tumor microenvironment modulation, spatiotemporal control, and imaging-guided activation strategies that distinguish MQDs from conventional nanotherapeutics. Finally, key challenges related to clinical advancement, manufacturing scalability, safety evaluation, and regulatory considerations are evaluated. By integrating fundamental structure-driven insights with therapeutic and clinical perspectives, MQDs are positioned as a versatile and promising platform for next-generation precision cancer theranostics.
Keywords:
cancer theranostics
catalytic tumor therapy
in vivo nanomedicine
MXene quantum dots
photothermal activation
structure-property relationships
Journal
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IF:
2.6
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1.1K
Citations:
3.0K
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