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Study on Physical Properties, Dissolution and Packaging Stability of Processed Armeniacae Semen Amarum
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DOI：10.1177/1934578X261444903.png)
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Abstract
En 中文
Objective: This study aimed to determine pre-processing parameters for Armeniacae Semen Amarum (ASA), specifically the optimal particle size and appropriate packaging conditions, in order to support intelligent dispensing and ensure product quality. Method: The physical properties of 10 batches of raw, blanched, and fried ASA, including moisture content, hardness, relative density, and extract yield, were evaluated. A validated HPLC method was used to determine the contents of amygdalin and prunasin in water decoctions prepared from whole seeds and from five crushed particle size fractions (< 0.85, 0.85-2, 2-4, 4-5, and 5-6 mm). Accelerated stability testing was conducted according to Chinese Pharmacopoeia guidelines at 40 degrees C +/- 2 degrees C and 75% +/- 5% relative humidity for 30 days. Paper bags, polyethylene bags, and aluminum foil bags were evaluated under both vacuum and non-vacuum conditions. Key stability indicators-moisture content, fatty oil content, acid value, and amygdalin content-were monitored throughout the storage period. Result: Processing significantly altered the physical properties of ASA (P <= 0.001). The contents of amygdalin and prunasin in water decoctions prepared from crushed samples of all three processed ASA products were significantly higher than those from whole seeds (P < 0.001). The recommended optimal particle size ranges were 4-5 mm for raw ASA, 2-4 mm for blanched ASA, and 0.85-2 mm for fried ASA. In the stability study, samples packaged in paper bags showed marked deterioration: after 30 days, moisture content increased to 9.03%, the acid value rose to 2.84, and amygdalin content decreased by 15.41%. In contrast, polyethylene and aluminum foil maintained all stability indicators within acceptable ranges, with no significant benefit from vacuum treatment. Conclusion: Processing altered the physical properties of ASA, and crushing enhanced the dissolution of its active components. Optimal particle size ranges and suitable packaging materials for processed ASA were identified.
Keywords:
Armeniacae Semen Amarum
prescription processing
intelligent dispensing
crushing
amygdalin
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