.png){kind=icon}
.png){kind=icon}
Return
Study on the anti-inflammatory effect of tetrahedral framework nucleic acid-loaded sinomenine in the treatment of rheumatoid arthritis
.png){kind=icon}
PRE
AI
C
J
S
L
DOI：10.1039/D5NH00709G.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by destructive and symmetrical joint lesions and joint synovitis; with the main clinical manifestations including joint deformity; morning stiffness; and inflammation in the joints of the hands; feet; wrists and ankles; and the temporomandibular joints. Sinomenine is a natural alkaloid with anti-inflammatory; analgesic; immunosuppressive and bone-protective effects; showing great potential in the treatment of rheumatoid arthritis. However; sinomenine suffers from drawbacks such as poor water solubility; low bioavailability and rapid degradation; which compromise its therapeutic efficacy. Tetrahedral framework nucleic acid (TFNA) is a DNA nanostructure with excellent delivery capacity for small-molecule drugs. It can bind small molecules from traditional Chinese medicine through electrostatic interactions and groove binding; thereby improving bioavailability. In this study; using TFNA as a carrier; we constructed a drug delivery system with favorable stability and biocompatibility – the TFNA–SIN complex – to deliver SIN into synovial fibroblasts; exerting anti-inflammatory effects and inhibiting cell proliferation. TFNA–SIN inhibits the expression of M1 macrophages; promotes the expression of M2 macrophages; and suppresses inflammatory cell infiltration by blocking the NF-κB and extracellular regulated protein kinase (ERK) signaling pathways. Therefore; TFNA improves the bioavailability of SIN and reduces SIN-induced toxicity; representing a promising alternative agent for the treatment of RA.
Journal
N
IF:
0
Papers:
99
Citations:
0
Organization
Cited Papers