.png){kind=icon}
Return
Studying Dissolution with a Model Integrating Solid-Liquid Interface Kinetics and Diffusion Kinetics
.png){kind=icon}
PRE
AI
DOI：10.1021/ac302297a.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
A dissolution model that integrates the solid liquid interface kinetics and the mass transport kinetics is introduced. Such a model reduces to the Noyes-Whitney equation under special conditions, but offers expanded range of applicability and flexibility fitting dissolution profiles when interfacial kinetics and interfacial concentration deviate from the assumptions implied in the Noyes-Whitney equation. General solutions to the integrated dissolution model derived for noninteractive solutes as well as for solutes participating in ionization equilibrium are discussed. Parameters defining the integrated dissolution model are explained conceptually along with practical ways for their determinations. Conditions under which the model exhibits supersaturation features are elaborated. Simulated dissolution profiles using the integrated dissolution model for published experimental data exhibiting supersaturation features are illustrated.
Keywords:
ROTATING-DISK
DRUG RELEASE
CONVECTIVE DIFFUSION
PHYSICOCHEMICAL ASPECTS
CARBOXYLIC-ACIDS
LAYER PH
RATES
SOLUBILITY
SURFACTANT
TRANSPORT
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
6.7
Papers:
4.7W
Citations:
15.9W
Organization
No organization information available
Cited Papers
.png){kind=icon}
ShareSave
ShareSaveShareSaveShareSaveShareSaveShareSave
View more