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Subclinical Gray Matter Damage: Macro- and Microstructural Findings in Stroke-Free Unilateral Middle Cerebral Artery Occlusion Patients
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DOI:10.1016/j.brainresbull.2026.111919.png)
Abstract
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• damage to both macro- and microstructures of gray matter is widely distributed throughout the bilateral brain parenchyma, including both cerebellar regions, in patients with unilateral MCA occlusion. • Patients with unilateral MCA occlusion demonstrate significantly reduced total gray matter volumes compared to normal controls. • Patients with unilateral MCA occlusion exhibit significantly reduced regional gray matter volumes in the hippocampus, parahippocampal gyrus, and limbic system compared to healthy controls. • Bilateral frontal and occipital cortical ODI show a decrease, indicating a reduction in the orderliness of neuronal arrangement. • Bilateral white matter NDI declined, indicating potential axonal loss or damage to the myelin sheath.
Keywords:
Middle cerebral artery (MCA)
Voxel-based morphometry (VBM)
Surface-based morphometry (SBM)
Neurite Orientation Dispersion and Density Imaging (NODDI)
Neurite Density Index (NDI)
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