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Subclinical Gray Matter Damage: Macro- and Microstructural Findings in Stroke-Free Unilateral Middle Cerebral Artery Occlusion Patients

delete2026-05-06
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Zhenghua Liu *
X
Xinghua Wan
Y
Yu Xiao
DOI:10.1016/j.brainresbull.2026.111919delete
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Abstract

Abstract

En 中文
• damage to both macro- and microstructures of gray matter is widely distributed throughout the bilateral brain parenchyma, including both cerebellar regions, in patients with unilateral MCA occlusion. • Patients with unilateral MCA occlusion demonstrate significantly reduced total gray matter volumes compared to normal controls. • Patients with unilateral MCA occlusion exhibit significantly reduced regional gray matter volumes in the hippocampus, parahippocampal gyrus, and limbic system compared to healthy controls. • Bilateral frontal and occipital cortical ODI show a decrease, indicating a reduction in the orderliness of neuronal arrangement. • Bilateral white matter NDI declined, indicating potential axonal loss or damage to the myelin sheath.
Keywords:
Middle cerebral artery (MCA)
Voxel-based morphometry (VBM)
Surface-based morphometry (SBM)
Neurite Orientation Dispersion and Density Imaging (NODDI)
Neurite Density Index (NDI)
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Brain Research Bulletin cover
Brain Research Bulletin
IF:
3.7
Papers:
6.8K
Citations:
1.2W

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nanchang university
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Papers: 2.0K
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nan chang county people's hospital
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1
Papers: 1
Citations: 0
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