Substituent effects in picolinic acid-derived silver(I) and zinc(II) complexes: Structure, stability, DNA interactions and therapeutic potential

Michaela Rendošová

doi:10.1016/j.jinorgbio.2026.113392

Substituent effects in picolinic acid-derived silver(I) and zinc(II) complexes: Structure, stability, DNA interactions and therapeutic potential

2026-06-18

0

PRE

AI

M

Michaela Rendošová

L

Lenka Auxtová

K

Kristína Harbuľáková

G

Gabriela Kuzderová

R

Róbert Gyepes

J

Jana Havlíčková

M

Mária Vilková

M

Martin Kello

S

Simona Žiláková

P

Petra Olejníková

T

Tomáš Pagáč

D

Danica Sabolová

L

Lenka Kollárová

Z

Zuzana Vargová *

DOI：10.1016/j.jinorgbio.2026.113392

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• Picolinic acid substituents effect on Ag(I) and Zn(II) coordination. • Distinct speciation for silver(I) and zinc(II) 3-MePicH and 3-OHPicH complexes. • Structures confirmed by spectroscopic, thermal and single-crystal analysis. • Silver(I) complexes show enhanced antimicrobial and anticancer activity. • Strong DNA binding and topoisomerase II inhibition by Ag3-MePic.

Substituent effects in picolinic acid-derived silver(I) and zinc(II) complexes: Structure, stability, DNA interactions and therapeutic potential

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