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Succinylation of TAGLN2 at K40 drives lipid oxidative stress resistance and TMZ chemoresistance via redox reprogramming in Glioblastoma

delete2026-08-01
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PRE
AI
W
Wanyao Meng
Y
Yayun Feng
Y
Yuanyuan Huang
X
Xinxiang Zhang
D
Dequan Shen
Y
Yichen Zhong
H
Hui Xu
Y
Yating Liu
J
Jiahong Wang
D
Di Fan
Y
Yanting Gu *
DOI：10.1016/j.freeradbiomed.2026.07.046delete
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Abstract

Abstract

En 中文
• TAGLN2-K40 succinylation drives TMZ resistance in glioma via activating the PP2A/PI3K/AKT/NRF2/β-catenin/GPX4 signaling axis. • Targeting this succinylation event with a cell-penetrating peptide disrupts redox balance and synergizes with TMZ to overcome chemoresistance, offering a promising therapeutic strategy for GBM.

Journal

Free Radical Biology and Medicine cover
Free Radical Biology and Medicine
IF:
8.2
Papers:
2.1W
Citations:
5.4W

Organization

S
shenyang pharmaceutical university
Scholars:
1.4K
Papers: 300
Citations: 0
G
General Hospital of Northern Theater Command
Scholars:
498
Papers: 133
Citations: 0
D
department of internal medicine
Scholars:
2.2K
Papers: 825
Citations: 0
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