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Sucralose promotes cardiac redox-metabolic remodeling through MRPL12-associated mitoribosomal stress
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DOI：10.1016/j.freeradbiomed.2026.07.052.png)
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Abstract
En 中文
• Sucralose exposure is linked to cardiac redox-bioenergetic impairment. • Proteomics prioritizes MRPL12-linked mitoribosomal alterations. • Sucralose lowers mitochondrial translation-associated nascent protein synthesis. • MRPL12 loss phenocopies mitochondrial, redox, and lipid abnormalities. • MRPL12 restoration partly attenuates cardiac remodeling and lipid deposition.
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