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Sulcal Depth and Genetic Susceptibility influence initial Treatment Response in Adults with Attention-Deficit/Hyperactivity Disorder
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DOI：10.1016/j.bpsc.2025.09.012.png)
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Abstract
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As neurobiological markers gain prominence in guiding personalised treatments, sulcal depth (SD) remains an underexplored yet pivotal factor in neural processing and therapeutic efficacy. While genetic influences shape cortical architecture, their role in modulating the relationship between SD and treatment outcomes remain unclear. This study investigates whether pre-treatment SD predicts symptom alleviation in adults with Attention-Deficit/Hyperactivity Disorder (ADHD) and explores moderating effects of genetic susceptibility for ADHD and cross-disorder influences.
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