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SUMOylation fine-tunes DNMT1 to silence viral mimicry transcripts

delete2026-07-21
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P
Priscillia Lhoumaud
M
Maxim V. C. Greenberg *
DOI：10.1038/s41588-026-02595-xdelete
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Abstract

Abstract

En 中文
DNMT1 binds unmethylated CpG islands at active genes and, upon catalytic inhibition, redistributes to partially methylated, inaccessible regions, triggering viral mimicry via endogenous retroelements and mega-intergenic RNAs. A SUMOlyated pool of DNMT1 then restores methylation and suppress this response, highlighting a druggable regulatory layer.

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Nature Genetics cover
Nature Genetics
IF:
29
Papers:
689
Citations:
241

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Institut Jacques Monod
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32
Papers: 16
Citations: 1.4K
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