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Suprascapular Nerve Release Improves the Histological Healing Morphology and Biomechanical Strength of the Rotator Cuff in a Rat Chronic Massive Rotator Cuff Tear Model
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DOI：10.1177/03635465261464186.png)
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Abstract
En 中文
<jats:sec>
<jats:title>Background:</jats:title>
<jats:p>While suprascapular nerve (SSN) entrapment is widely recognized as a complication of massive rotator cuff tears (MRCTs), its role as an independent factor affecting tendon healing remains underreported. Additionally, the therapeutic benefit of SSN release in MRCT repair remains controversial.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Purpose:</jats:title>
<jats:p>To investigate the incidence of SSN entrapment via histological stain and whether SSN release enhances rotator cuff healing in a rat model of delayed MRCT repair.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Study Design:</jats:title>
<jats:p>Controlled laboratory study.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods:</jats:title>
<jats:p>A chronic MRCT model was established in rats via bilateral transection of the supraspinatus and infraspinatus tendons. After 4 weeks, 5 rats (10 shoulders) were euthanized to assess SSN entrapment incidence via immunofluorescence staining. The remaining 28 rats were randomized into 2 groups: tendon repair (TR) group (n = 14; bilateral tendon reattachment) and tendon repair + nerve release (TR+NR) group (n = 14; same repair with concurrent SSN release). Postoperative evaluations at 4 and 8 weeks included biomechanical testing (maximum load and stiffness) and histological analysis (healing quality, nerve regeneration).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results:</jats:title>
<jats:p>
SSN entrapments were observed in 7 of 10 shoulders using Neurofilament-200 staining. The TR+NR group demonstrated significantly higher maximum load values at 8 weeks postrepair (
<jats:italic toggle="yes">P</jats:italic>
< .05). Additionally, the TR+NR group achieved significantly superior histological scores compared to the TR group at both 4 and 8 weeks postrepair (
<jats:italic toggle="yes">P</jats:italic>
< .05).
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion:</jats:title>
<jats:p>SSN release significantly improved rotator cuff healing in rats with chronic MRCTs, as evidenced by enhanced biomechanical strength and histological regeneration.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Clinical Relevance:</jats:title>
<jats:p>These findings may provide some hints supporting SSN release in patients undergoing MRCT repair.</jats:p>
</jats:sec>
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