.png){kind=icon}
.png){kind=icon}
Return
Sustainable lyocell-based oxidized regenerated cellulose hemostat: manufacturing, characterization, and biocompatibility
.png){kind=icon}
PRE
AI
B
S
İ
DOI：10.1007/s10570-026-07164-3.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Severe hemorrhage remains a major cause of mortality in trauma, surgery, and battlefield injuries, highlighting the need for rapid, biocompatible, and absorbable hemostatic materials. Conventional agents often suffer from high acidity, inflammatory response, thrombogenic risk, and limited biodegradability. In this study, an end-to-end, systematically reported and reproducible manufacturing route is presented for a sustainable, binder-free oxidized regenerated cellulose (ORC) hemostat, produced from lyocell fiber (Tencel™), a closed-loop RC from wood pulp with 99% solvent recovery, a material rarely employed for hemostatic applications. The lyocell-based nonwoven was needle-punched, oxidized, and gamma-sterilized to yield a medical-grade absorbable material. Physicochemical and morphological characterizations confirmed successful oxidation and preservation of the cellulose backbone. The ORC demonstrated appropriate carboxyl content, pH, solubility, negligible nitrogen, absence of formaldehyde, and stable residual moisture. Biological evaluations revealed concentration- and time-dependent cytotoxicity mainly linked to acidic degradation by-products, while showing low hemolysis, negligible skin irritation, and no inflammatory or necrotic response after implantation. These findings confirm excellent biocompatibility and safe interaction with soft tissue and blood. The study establishes a transparently parameterized and validated workflow through USP- and ISO-aligned analyses, providing a sustainable and credible alternative to rayon-based ORCs and bridging the gap between textile-process transparency and medical-grade evidence.
Keywords:
Absorbable hemostat
Medical textile
Needle-punched nonwoven
Oxidized regenerated cellulose (ORC)
Hemostatic biomaterial
Surgical wound care
Journal
IF:
4.8
Papers:
8.4K
Citations:
3.4W
Organization
Cited Papers