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Synergistic Effects of SGLT2 Inhibitors and GLP-1R Agonists on Inflammation-Associated Oxidative Stress in Atrial Fibrillation
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DOI：10.1016/j.jacbts.2026.101587.png)
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Abstract
En 中文
• RAA from AF patients show higher inflammation and oxidative stress vs non-AF • RAA inflammation correlates with SGLT2 and GLP-1R expression. • SGLT2 and GLP-1R modulation exert synergistic antioxidant effects in RAA • Combined SGLT2i/GLP-1Ra therapy represents a promising strategy against AF remodeling
Keywords:
atrial fibrosis
atrial remodeling
glucagon-like peptide-1 receptor
inflammation
oxidative stress
sodium-glucose cotransporter 2
AF
atrial fibrillation
cAMP
cyclic adenosine monophosphate
GLP-1R
glucagon-like peptide 1 receptor
GLP-1Ra
glucagon-like peptide 1 receptor agonist(s)
HF
heart failure
IPTW
inverse probability of treatment weighting
LA
left atrial/atrium
PBMC
peripheral blood mononuclear cell
PKA
protein kinase A
RAA
right atrial appendage
ROS
reactive oxygen species
SGLT2
sodium-glucose cotransporter 2
SGLT2i
sodium-glucose cotransporter 2 inhibitor(s)
SR
sinus rhythm
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