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Synergistic tuning of nitrogen-functionalized graphene and molybdenum disulfide with ruthenium oxide nanoparticles for highly sensitive electrochemical detection of folic acid
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DOI：10.1007/s10800-026-02482-7.png)
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Abstract
En 中文
Designing an ultra-sensitive and stable sensors for folic acid quantification was crucial for addressing various health issues. In this study, an electrochemical sensor was developed by functionalizing reduced graphene oxide with nitrogen-containing groups and transition-metal dichalcogenide materials to enhance sensitivity. To further boost sensitivity and implications for real-world sensing applications, ruthenium oxide nanoparticles were incorporated into the Molybdenum disulfide -Nitrogen-Doped Graphene matrix. Comprehensive physical characterization of the nanocomposite was performed using Raman spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. Electrochemical properties were investigated using cyclic voltammetry, differential pulse voltammetry, linear sweep voltammetry, electrochemical impedance spectroscopy, and Tafel plots. The optimised Nitrogen-functionalized graphene-molybdenum disulfide-ruthenium Oxide nanocomposite exhibited superior electrical conductivity, sensitivity, and selectivity for folic acid detection, with a wide linear range of 0.2-2.0 nM and a detection limit of 0.027 nM. Notably, the proposed sensor maintained a stable performance over 30 days demonstrating negligible interference from K+, Na+, Mg2+, Zn2+, NH4+, Cl-, NO3-, and SO42- ions and biomolecules like glucose, fructose, sucrose, serotonin, uric acid, and dopamine. This sensor demonstrated significant potential for accurate folic acid quantification in biomedical and pharmaceutical applications. [GRAPHICS]
Keywords:
Folic acid
Sensing
Graphene
Ruthenium oxide
Molybdenum disulfide
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