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Synthesis and Antibacterial Properties of Ga-Doped TiO2 Nanorods under NIR-Responsive Synergistic Effects
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DOI：10.1142/S1793292026500967.png)
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Abstract
En 中文
Titanium (Ti) is a biologically inert material, lacking antibacterial activity and osteoconductive properties, which may lead to implant failure. To address these issues, a surface-modified film is developed that combines inherent antibacterial properties with synergistic antibacterial functionality in response to Near-Infrared (NIR) light. Titanium Dioxide (TiO2 ) nanorods were prepared on a titanium surface via the hydrothermal method. Utilizing the physical perforating properties of TiO2 nanorods combined with the specific ability of Gallium (Ga) to disrupt bacterial Iron (Fe) metabolism, different concentrations of Ga3+ were doped. The microstructure, composition and related physicochemical properties of the film layer were investigated. To further enhance antibacterial efficacy, photothermal therapy and photodynamic therapy were integrated by irradiating the film with 808nm NIR light. Results demonstrated that Ga-doped TiO2 films exhibited outstanding synergistic antibacterial activity under 808nm NIR irradiation. Specifically, the highest antibacterial rate of irradiated samples against Escherichia coli (E. coli) reached 98.1%, and the highest antibacterial rate against Staphylococcus aureus (S. aureus) reached 98.5%. Furthermore, the films demonstrated favorable osteoconductive properties in in vitro mineralization experiments. This approach offers a new strategy for addressing issues of implant infection and inadequate osteogenic performance.
Keywords:
TiO2 nanorod
Gallium doping
near-infrared light
antibacterial
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