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Synthesis and characterization of silver nanowires and their promising anticancer effects
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DOI：10.1039/D6NH00195E.png)
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Abstract
En 中文
Silver nanowires (AgNWs) were synthesized by a modified polyol method and evaluated for their structural features and anticancer activity against Ehrlich ascites carcinoma (EAC) cells in vivo. The AgNWs were characterized by UV–vis spectroscopy; zeta potential analysis; dynamic light scattering; FESEM; TEM; and EDS to confirm their optical response; morphology; and elemental composition. The nanowires showed a plasmonic absorption band at 385 nm; a near-neutral zeta potential; and a mean diameter of 71.58 ± 22.78 nm; although minor secondary morphologies were observed. In the EAC mouse model; AgNWs reduced viable EAC cell counts in a non-linear dose-dependent manner; with the lower dose showing stronger inhibition than the higher dose. These findings suggest that AgNWs possess measurable anticancer activity; while also indicating that dispersion state and dose-dependent behavior require further mechanistic study before translational use can be considered.
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