Synthesis of 2-Acylpyrroles and 5,6-Dihydro-4H-furo[3,4-c]pyrrol-4-ones via Silver/Base Promoted Intramolecular Hydroalkylation and Oxidation of Propargylamines

2026-05-01

PRE

Niannian Yi

Zhiwen Zhou

Wu, Peishan

Li, Jie

Li, Ziyan

Rong Yang

Chen, Xingyi

Xiong, Yi

Bing Yi *

DOI：10.1021/acs.joc.6c00552

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Abstract

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A novel approach to the synthesis of 2-acylpyrroles and 5,6-dihydro-4H-furo[3,4-c]pyrrol-4-ones through silver/base promoted tandem reactions of intramolecular hydroalkylation and oxidation of propargylamines has been developed successfully. The strategy has the advantages of one-pot synthesis, easily available raw materials, good atomic economy, wide functional group tolerance, and excellent regioselectivity. Moreover, this method can also be used to construct 2-acylfuran, further expanding its applicability.

Keywords:

CATALYZED SYNTHESIS

PYRROLE

DERIVATIVES

CYCLIZATION

BIOSYNTHESIS

DIAZOAMIDES

ANNULATION

ACYLATION

NITROGEN

LACTONE

Synthesis of 2-Acylpyrroles and 5,6-Dihydro-4H-furo[3,4-c]pyrrol-4-ones via Silver/Base Promoted Intramolecular Hydroalkylation and Oxidation of Propargylamines

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