Synthesis of Zwitterionic conjugates of cobalt Bis(dicarbollide) with BODIPY and their Photophysical properties and biological studies

Ilya A. Mezentsev

doi:10.1016/j.jphotochem.2026.117316

Synthesis of Zwitterionic conjugates of cobalt Bis(dicarbollide) with BODIPY and their Photophysical properties and biological studies

2026-04-28

0

PRE

AI

I

Ilya A. Mezentsev

N

Nadezhda V. Dudarova

A

Anna A. Druzina *

I

Irina D. Kosenko

A

Alexey S. Romanenko

А

Алексей А. Анисимов

I

Ivan V. Ananyev

M

Marina V. Volostnykh

K

Kirill E. Erdelyi

A

Anastasia A. Antonets

A

Alexey A. Nazarov

D

Daria A. Metlina

N

Nikolay P. Datskevich

I

Ilya V. Taydakov

M

Mariia R. Mollaeva

S

Sergei I. Obydennyi

Y

Yulia G. Gorbunova

I

Igor B. Sivaev

V

Vladimir I. Bregadze

DOI：10.1016/j.jphotochem.2026.117316

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Abstract

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• Zwitterionic boron-rich BODIPY conjugates with cobalt bis(dicarbollide) for BNCT. • Conjugates with BODIPY are non-toxic against both cancerous and non-malignant cells. • Fluorescent conjugate binds to bovine serum albumin. • Derivative is successfully uptake in A2780 cell line at the good 10B concentration. • CLSM image of A2780 cells shows distributed perinuclear accumulation of conjugate.

Keywords:

BODIPY

cobalt bis(dicarbollide)

BNCT

zwitterionic conjugates

fluorescence imaging

Synthesis of Zwitterionic conjugates of cobalt Bis(dicarbollide) with BODIPY and their Photophysical properties and biological studies

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