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Systematic analysis of hippo pathway signaling identifies TEAD1 as a transcriptional regulator of neuroendocrine prostate cancer

delete2026-05-30
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OA
AI
L
Lisha G. Brown
I
Ilsa M. Coleman
T
Tony L.H. Chu
E
Erolcan Sayar
R
Radhika A. Patel
B
Brian Hanratty
M
Mohamed Adil
D
Dapei Li
Y
Yongtao Li
H
Holly M. Nguyen
C
Conner J. Sessions
E
Erin L. Sweeney
J
Joshi J. Alumkal
R
Rui M. Gil da Costa
Y
Yuzhuo Wang
D
Daniel W. Lin
L
Lawrence D. True
R
Ruth F. Dumpit
E
Eva Corey
J
John K. Lee
DOI：10.1016/j.neo.2026.101321delete
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Abstract

Abstract

En 中文
Treatment-induced neuroendocrine prostate cancer (NEPC) represents an aggressive form of castration-resistant prostate cancer (CRPC) associated with lineage plasticity and therapeutic resistance. In this study, we investigated the role of the Hippo signaling axis in the transdifferentiation from androgen receptor–positive prostate cancer (ARPC) to NEPC.
Keywords:
Prostate
Neuroendocrine
YAP
TEAD1
RBFOX2
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Journal

Neoplasia cover
Neoplasia
IF:
7.7
Papers:
2.8K
Citations:
8.0K

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