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Systematic Comparison of High-Fat Diet– and Streptozotocin-Induced Prediabetic Obese C57BL/6J Mouse Models: A Sex-Based Protocol Optimization Study
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DOI：10.1111/dom.71183.png)
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Abstract
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Animal models of prediabetes (Pre-DM) are essential for studying metabolic disease and testing therapies, yet high-fat diet (HFD) and HFD-plus-streptozotocin (STZ) protocols vary in feeding duration, STZ dose, and diagnostic criteria and rarely account for sex. We compared five protocols in male and female C57BL/6J mice to find the best balance of duration, cost, and phenotypic stability and to characterize how HFD and HFD-STZ differ in their effects on glucose and lipid metabolism.
Keywords:
C57BL/6J mice
glucose intolerance
high-fat diet
insulin resistance
MASLD
model selection
obesity
prediabetes
sex differences
streptozotocin
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