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T cell control of the intestinal barrier and gut microbiota during ageing
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DOI：10.1016/j.it.2026.05.001.png)
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Abstract
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The intestinal epithelium, resident immune cells, and the commensal microbiota coexist in harmony to prevent unwanted inflammatory responses in the host. T cells have emerged as key players in the establishment of beneficial host–microbiota relationships and the preservation of intestinal barrier integrity. Age-related shifts in the T cell compartment can lead to gut dysbiosis and intestinal barrier disruption, driving inflammageing and tissue senescence in aged organisms. Understanding the interplay between T cells, the intestine, and its microbiota could allow the design of new therapeutic strategies to foster healthier ageing.
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