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Takotsubo: a systematic review of the neurological and psychological implications of a broken heart
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DOI：10.1080/14796678.2026.2635981.png)
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Abstract
En 中文
Introduction: Takotsubo Syndrome (TTS) presents as an acute heart disease characterized by left ventricular dysfunction. The exact cause is not yet known; however, it is thought that it may be caused by acute emotional or physical events and the subsequent release of catecholamines. This review investigated the presence of psychological and neurological disorders associated with TTS. Methods: Studies evaluating the presence of psychological and neurological disorders in TTS were reviewed. Search was performed on the Cochrane, PubMed, Embase, Scopus, and Web of Science Databases. Of the initial 763 studies, 12 met the inclusion criteria. Results: All studies analyzed demonstrated the presence of psychological disorders, and six also demonstrated the presence of neurological disorders. In particular, associations emerged with psychological disorders such as depression and anxiety. Major neurological disorders identified included migraine, epilepsy, and cerebral hemorrhage. In addition, structural and volumetric brain changes were observed in people with TTS through neuroimaging studies. Conclusions: Further studies evaluating the still poorly understood etiology of the syndrome are needed so that an appropriate early diagnosis can be made. Further studies should investigate the effectiveness of psychotherapeutic treatments in order to improve symptom management, prognosis, and more adequately manage any relapse.
Keywords:
Takotsubo syndrome
neuropsychology
assessment
neurological disorders
anxiety
depression
stress
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