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Tangeretin ameliorates sepsis-induced neurocognitive impairment in adult male mice by suppressing Akt-driven glycolytic reprogramming and neuroinflammation
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DOI：10.1111/bph.70477.png)
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Abstract
En 中文
Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, frequently leads to long-term cognitive impairment. Tangeretin, a polymethoxylated citrus flavonoid, has neuroactive and anti-inflammatory properties. We investigated whether tangeretin protects against sepsis-associated neurocognitive deficits and delineated the underlying mechanisms, focusing on Akt signalling and microglial metabolism.
Keywords:
cognitive deficits
glycolysis
microglia
sepsis
serine–threonine kinase
tangeretin
Journal
IF:
7.7
Papers:
1.4W
Citations:
3.7W
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Cited Papers