Tannic acid-crosslinked layer-by-layer nanocomposite coatings enhance mechanical stability and pre-osteoblast response in porous polymer-based scaffolds for bone tissue engineering

MohammadAli Sahebalzamani

doi:10.1016/j.bioadv.2026.215025

Tannic acid-crosslinked layer-by-layer nanocomposite coatings enhance mechanical stability and pre-osteoblast response in porous polymer-based scaffolds for bone tissue engineering

2026-06-18

0

OA

AI

M

MohammadAli Sahebalzamani

J

John Redmond

S

Srishti Agarwal

H

Helen O. McCarthy

T

Tanya J. Levingstone

N

Nicholas Dunne *

DOI：10.1016/j.bioadv.2026.215025

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Abstract

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• TA crosslinked LbL-coated PU scaffolds showed enhanced hydrophilicity and improved mechanical stability under hydration • TA crosslinking improved the structural stability of LbL-coated PU scaffolds in enzymatic and dynamic degradation studies. • In vitro tests confirmed LbL‑coated PU scaffolds were cytocompatible and support pre‑osteoblast attachment and proliferation

Keywords:

Layer-by-layer assembly

Multifunctional nanocomposite coatings

Open-cell structures

Chemical crosslinking

Bone tissue-engineering

Tannic acid-crosslinked layer-by-layer nanocomposite coatings enhance mechanical stability and pre-osteoblast response in porous polymer-based scaffolds for bone tissue engineering

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