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Target-Triggered Triplex DNA Disassembly on a Lateral Flow Strip Enables Ultrasensitive, Visual Thrombin Detection
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DOI：10.1016/j.snr.2026.100469.png)
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Abstract
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• A triplex DNA switch enables ultrasensitive protein detection. • CNT-DNA conjugate acts as both signal label and sensing element. • Achieves 0.15 nM thrombin detection, 16.7-fold more sensitive. • High specificity and reliable performance in 10% human serum. • Universal platform; aptamer exchange allows other target detection.
Keywords:
Triplex DNA
Lateral flow chromatography strip
Carbon nanotube
Molecular-switch
Thrombin
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