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Targeted Intra-Atrial Delivery of GMP-Grade Human Extracellular Vesicles Prevents Inflammation-Driven Postoperative Atrial Fibrillation in Pigs
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DOI：10.1016/j.jacbts.2026.101555.png)
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Abstract
En 中文
• Postoperative AF is driven by innate immune activation and inflammatory–fibrotic atrial remodeling. • Immune-modulating, GMP-grade cardiac extracellular vesicles prevent postoperative AF via targeted intra-atrial delivery. • Next steps include defining immune targets, optimizing catheter delivery, and confirming durable clinical efficacy.
Keywords:
atrial fibrillation
biologic therapy
cardiac fibrosis
extracellular vesicles
inflammation
postoperative atrial fibrillation
AF
atrial fibrillation
ALT
alanine aminotransferase
AST
aspartate aminotransferase
CD
cluster of differentiation
CV
coefficients of variation
EV
extracellular vesicle
GMP
good manufacturing practice
IL
interleukin
LPS
lipopolysaccharide
NLRP3
NOD-like receptor pyrin domain–containing 3
WCB
working cell bank
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