arrow
Return

Targeted proteomics data interpretation with DeepMRM

delete2023-07-01
delete1
delete
OA
AI
J
Jungkap Park
C
Christopher Wilkins
D
Dmitry M. Avtonomov
J
Jiwon Hong
S
Seunghoon Back
H
Hokeun Kim
N
Nicholas Shulman
B
Brendan MacLean
S
Sang‐Won Lee
S
Sangtae Kim *
DOI:10.1016/j.crmeth.2023.100521delete
deleteOriginal
deleteShare
deleteSave
View PDF
Abstract

Abstract

En 中文
Targeted proteomics is widely utilized in clinical proteomics; however, researchers often devote substantial time to manual data interpretation, which hinders the transferability, reproducibility, and scalability of this approach. We introduce DeepMRM, a software package based on deep learning algorithms for object detec-tion developed to minimize manual intervention in targeted proteomics data analysis. DeepMRM was evalu-ated on internal and public datasets, demonstrating superior accuracy compared with the community stan-dard tool Skyline. To promote widespread adoption, we have incorporated a stand-alone graphical user interface for DeepMRM and integrated its algorithm into the Skyline software package as an external tool.
Keywords:
MS
QUANTIFICATION
ABSOLUTE
AI Summary

AI Summary

Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Cell Reports Methods cover
Cell Reports Methods
IF:
4.5
Papers:
930
Citations:
2.0K

Organization

K
Korea University
Scholars:
3.6W
Papers: 3.8W
Citations: 4.4W
U
University of Washington
Scholars:
8.0W
Papers: 7.0W
Citations: 12.5W