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Targeting autoreactive B cells in rheumatoid arthritis through MHC class I-presented BCR-derived neo-epitopes
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DOI：10.1016/j.jaut.2026.103581.png)
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Abstract
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• Somatically mutated RA BCRs encode HLA class I–presentable peptides across alleles. • BCR-derived neoepitopes are processed and presented by engineered (B) cell lines. • Human CD8+ T cells selectively recognize mutated, but not germline, BCR peptides. • Results support selective CD8+ T cell targeting of autoreactive B cells in autoimmunity.
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