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Targeting cellular senescence in cervical Cancer: a novel pathway to preserve reproductive potential

delete2026-06-17
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PRE
AI
Y
Yiran Fei
Y
Yiming Mao
W
Wenyu Cai
L
Liquan Huang
Y
Yibo He *
Q
Qun Zhou *
Z
Zhezhong Zhang *
DOI：10.1016/j.intimp.2026.117005delete
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Abstract

Abstract

En 中文
• SASP-driven senescence rewires cervical-cancer immunity and tumor growth. • Senolytic & SASP-blocker combo boosts chemo-radiotherapy, reverses resistance. • Senescence-targeted regimen plus fertility-sparing surgery preserves fecundity. • Senotherapeutic-immunotherapy synergy heightens anti-HPV T cell responses. • Framework for trials integrating immunomodulation with onco-fertility goals.

Journal

International Immunopharmacology cover
International Immunopharmacology
IF:
4.7
Papers:
1.6W
Citations:
4.1W

Organization

S
shanghai jiao tong university
Scholars:
15.1W
Papers: 11.5W
Citations: 159
T
The First Affiliated Hospital of Zhejiang Chinese Medical University
Scholars:
143
Papers: 47
Citations: 0
Cited Papers

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