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Targeting chemobrain: from experimental models to therapeutic discovery

delete2026-08-11
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PRE
AI
N
Nishant N. Parikh
H
Hyung‐Goo Kim
A
Amelia Michelle Sojung Moon
S
Sang Hoon Lee
S
Sang Hoon Kim
E
Euiyeon Lee
M
Mohammad Abdur Rashid
Y
Yongkyu Park
X
X.F. Steven Zheng *
M
Mi-Hyeon Jang *
DOI：10.1016/j.drudis.2026.104764delete
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Abstract

Abstract

En 中文
• Chemobrain lacks approved therapies despite high prevalence. • Chemotherapy disrupts cognition via oxidative and inflammatory pathways. • Multi-model platforms enable efficient target and drug discovery. • Rodent studies establish causal links between agents and deficits. • Targeting mitochondria, mTOR/AMPK, redox and immunity shows therapeutic promise.
Keywords:
Chemotherapy-induced cognitive impairment
chemobrain
neuroinflammation
oxidative stress
mitochondrial dysfunction
DNA damage
neurogenesis
synaptic plasticity
animal models
translational research
multi-model discovery pipeline
therapeutic targets

Journal

Drug Discovery Today cover
Drug Discovery Today
IF:
7.5
Papers:
6.3K
Citations:
2.3W

Organization

R
rutgers university
Scholars:
1.2K
Papers: 700
Citations: 0
R
Rutgers Cancer Institute of New Jersey
Scholars:
1.1K
Papers: 842
Citations: 2.6K
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