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Targeting DDAH II with Puerarin ameliorates doxorubicin-induced endothelial damage and ferroptosis through ADMA/NOS dysregulation rescue
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DOI：10.1016/j.jare.2026.08.013.png)
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Abstract
En 中文
• Pue-pre protects the vascular endothelium and alleviates DIE damage-induced ferroptosis. • Pue targets binding to DDAHⅡ and regulates ADMA/eNOS/NO pathway. • Pue-pre activates adaptive autophagy, attenuates Fe2+ level, oxidative stress and abnormal lipid metabolism. • Pue-pre improves energy metabolism and prevents mitochondrial dysfunction. • Pue provides dual protection against DIE damage.
Keywords:
Doxorubicin-induced endotheliotoxicity
Dimethylarginine dimethylaminohydrolase 2
Ferroptosis
Molecular targeted therapy
Puerarin
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