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Targeting Gi/o-coupled GPCRs to inhibit nociceptors: Insights from the serotonin receptor Htr1b and triptans

delete2026-07-30
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OA
AI
J
Jing Peng
B
Brianna T. Sanchez
A
Anda M. Chirila
X
Xiangsunze Zeng
M
Michelle M. DeLisle
L
Lijun Qi
J
Jia Yin Xiao
K
Karina Lezgiyeva
S
Sarah Low
C
Clifford J. Woolf
N
Nikhil Sharma
D
David D. Ginty *
DOI：10.1016/j.xcrm.2026.102949delete
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Abstract

Abstract

En 中文
• Gi/o-coupled GPCRs enriched in CGRP+ mouse and human DRG neurons are identified • Agonists of Gi/o-coupled GPCRs attenuate mouse nociceptor excitability in vitro • Triptans reduce specific pain-related behaviors through Htr1b in DRG neurons • The orphan GPCR Gpr19 emerges as a candidate analgesic target
Keywords:
pain
somatosensory neurons
nociceptors
DRG
GPCRs
serotonin receptors
Htr1b
triptans
Gpr19
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Journal

Cell Reports Medicine cover
Cell Reports Medicine
IF:
10.6
Papers:
2.2K
Citations:
8.9K

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H
harvard medical school
Scholars:
4.6K
Papers: 2.1K
Citations: 2
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