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Targeting Melanocortin-4 Receptor (MC4R) Family in Goldfish (Carassius auratus) for Enhanced Growth and Optimized Lipid Distribution
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DOI：10.1016/j.mce.2026.112816.png)
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Abstract
En 中文
• Two isoforms of MC4R, namely caMC4R and caMC4R-like, have been identified in goldfish. • The knockdown of caMC4R and caMC4R-like promotes appetite and weight gain in goldfish. • Goldfish MC4R regulates muscle lipid accumulation via the pyruvate metabolic pathway. • Goldfish MC4R-like regulates hepatic lipid accumulation via PPARγ/SREBP-1c.
Keywords:
caMC4R
caMC4R-like
lipid accumulation
pyruvate metabolic pathway
PPARγ/SREBP-1c
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