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Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine
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DOI：10.1111/bph.70612.png)
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Abstract
En 中文
The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro-nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this comorbidity. Here, we validate a model of persistent TMD comorbid with migraine in rats and dissect the role of peroxynitrite in its underlying nociceptive mechanisms, and as a novel therapeutic target.
Keywords:
calcitonin gene-related peptide
comorbidity
migraine
peroxynitrite
temporomandibular disorders
trigeminovascular
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