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Targeting the gut-brain axis: probiotic intervention alleviates depressive-like behaviors and social deficit after cranial irradiation
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DOI：10.1016/j.intimp.2026.117037.png)
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Abstract
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• Cranial irradiation disrupts the gut-brain axis, causing neuroinflammation, impaired neurogenesis, and behavioral deficits. • The probiotic mixture reverses behavioral deficits by reducing neuroinflammation and restoring hippocampal neurogenesis. • Targeted metabolomics identifies reduced noradrenergic overactivity as a key probiotic-associated feature.
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